Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 5 Articles
Circulating tumor cells are cells that detach from the primary tumor site and\nmigrate to the bone marrow or other tissues where they can initiate a metastatic\nsite. Liquid biopsies are an emerging tool in the past decades that enables\nus to detect Circulating Tumor Cells in patientsâ?? blood. Flow cytometry is a\npowerful tool used in liquid biopsy diagnostics. This aims to prove the sensitivity\nand specificity of a flow cytometric panel for the detection of CTCs in\nbreast cancer patients using healthy individualsâ?? samples as controls. The\nstudy was blinded to the data analyzing researcher. Statistical analysis followed\nand results show 86.9% area under the curve which indicates that the\nparticular method can be very promising for diagnosing breast cancer....
Background: Gynecological cancer inpatients and outpatients may have distinct supportive nursing care needs.\nThis study aimed to compare the supportive care needs between these two patient cohorts.\nMethods: This cross-sectional comparison analytic study aimed to identify the differences between the supportive\nnursing care needs of the gynecological cancer inpatients and outpatients. Data were collected from 200\nparticipants who were recruited through consecutive sampling method.\nResults: The results showed that gynecological cancer inpatients needed more supportive nursing care than the\noutpatients. The most reported supportive nursing care needs of the inpatients were in the domains of physical\n(80%) and the psychological (84%). Whilst, the outpatients needed more health information support (78%). There\nwas a significant difference between the supportive nursing care needs of gynecological cancer inpatients and\noutpatients (p value = 0.001). Supportive nursing care needs of the inpatients were 44 times higher compared to\nthose of the outpatients.\nConclusions: The gynecological cancer inpatients and outpatients need supportive nursing care differently.\nTherefore, nurses should assess supportive care needs of their patients early during the care in each setting so that\nthe intervention could be tailored to the patientâ??s individual needs. Our study findings can help nurses navigate the\nsupportive care needs for gynecological cancer patients receiving inpatient and outpatient care....
Background: Chemoradiation is a combination therapy of chemotherapy and radiotherapy. Because chemotherapy\nis given together with radiotherapy, the side effects are heavier and more severe for some patients. For\nnasopharyngeal cancer patients, the side effects involve nausea, vomiting, anorexia, diarrhea, mucositis, xerostomia,\nand tasting and hearing loss, which influence their quality of life. The purpose of this study was to explore the\nexperiences of patients with head and neck cancer undergoing chemoradiation.\nMethods: A Phenomenogical desctipve, involving in depth interviewes was conducted during a 6 month study\nperiod. Eleven patiets with nasopharyngeal cancer participated in indepth inteviews Colaizziâ??s method was used in\nanalyzing data. The selection of participants in this study using purposive sampling method the inclusion criteria\nwere1) the patient had been diagnosed with head and neck cancer, 2) minimum age of 18 years, and 3 had been\nreceived external chemoradiation, minimum 14 times of chmemoradiation. The study was conducted at one outpatientradiotherapy\ndepartment. at Dharmais Cancer Centre Hospital, Jakarta.\nResult: The findings show three main themes: 1) xerostomia was the main physical complaint, 2) patients had\ndecreased social interaction, and 3) having adequate support from the family was important for patients.\nConclusion: The findings suggest involving family members when patients are undergoing chemoradiation.\nAdequate family support is needed to help the patients adapt to the side effects of chemoradiation with the best\npossible response....
Background: Immune checkpoint inhibitors (ICI)s were recently approved\nfor the treatment of advanced non-small cell lung cancer (NSCLC). Whereas\nbrain metastases (BM) are frequent in NSCLC patients, data are missing regarding\nICIs intracranial efficacy and tolerance in patients with BM from\nNSCLC. Methods: This retrospective study was performed in the Multidisciplinary\nOncology and Therapeutic Innovation department, Marseille, France\nbetween April 2013 and February 2016. Data from patients with NSCLC with at\nleast one BM, and treated with ICIs (anti-PD1, anti-PDL1 or anti-CTL4) were\nanalyzed. Clinical, biological data and outcomes were retrieved from electronic\npatientsâ?? records. We assessed ICIs intracranial efficacy and tolerance.\nResults: Data from 55 patients were analyzed. Objective Response Rate\n(ORR) and Disease Control Rate (DCR) were respectively of 1.8 and 36.4%.\nMedian overall survival was 17.2 months and median progression free survival\nwas 2.9 months. Intracranial ORR (icORR) and intracranial DCR (icDCR)\nwere respectively 16.4% and 45.5%. Both were independent of smoking status,\nintracranial treatment, performance status, pathology, molecular profile\nand the presence or number of BM at diagnosis. However, there was a trend\ntowards an association between icORR and ECOG PS (p = 0.05), tobacco status\n(p = 0.057) and intracranial treatment. Adverse events were seen in 38.2%\npatients without identified predictive factor. Neurological symptoms appeared\nin 5.5% patients during immunotherapy and improved in 3.63% patients. \nConclusions: ICIs can be used safely on patients with BM from\nNSCLC. However, intracranial response is heterogeneous in such patients\nand we showed ECOG PS, tobacco smoking and intracranial treatment to be\nassociated with an improved icORR. This is the first study looking for predictive\nfactors of intracranial response of ICIs in patients with BM from NSCLC....
Background: The risk of lymph node positivity in early-stage colon cancer is a parameter that impacts therapeutic\nrecommendations. However, little is known about the effect of age on lymph node positivity in colon cancer with\nmucosal invasion. In this study, we aimed to quantify the effect of younger age on lymph node positivity in colon\ncancer with mucosal invasion.\nMethods: All patients were identified between 2004 and 2014 in the Surveillance, Epidemiology, and End Results\ndatabase. Patients were stage T1-T2, did not undergo preoperative radiotherapy, had at least one lymph node\nexamined, and underwent a standard colon cancer operation. Demographics and pathological data were compared\nbetween different age ranges. A nomogram model was built to estimate the probability of nodal involvement\naccording to different characteristics. Decision curve analysis was performed by calculating the net benefits for a\nrange of threshold probabilities.\nResults: This study identified 41,490 patients who met the eligibility criteria for our study. 1.4% (n = 620) of patients\nwere under 40 years old; 5.9% (n = 2571) were between 40 and 49 years old. Within each T stage, positive lymph\nnode rates decreased with increasing age. In univariate analyses, the positive lymph node rates for patients 20 to\n39 years of age were significantly higher than in patients in the reference group for stages T1 and T2. After dividing\nthe colon into the left and right parts, these trends remained. The lymph node metastatic rate was higher in the\nright colon than in the left colon in terms of different age ranges. The nomogram prediction system represents a\nnovel model with which to estimate lymph node metastasis in early T stage colon adenocarcinomas based on four\nrisk factors with a C-index of 0.657 (95% CI: 0.658â??0666).\nConclusions: Our study demonstrates that the risk of lymph node metastasis was higher in young (< 40 years)\npatients with early-stage colon adenocarcinomas. Therefore, more aggressive screening and therapeutic strategies\nshould be considered for young patients with colon adenocarcinoma....
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